Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c: A gene-environment interaction study
Authors' conclusion
Combining GLP1R agonists with adequate sleep may provide additional benefits for glycemic control in clinical practice.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 263,846 participants
- Comparison
- GLP1R-rs10305492 variant combined with lifestyle factors
- Outcome
- Glucose and HbA1c levels
Methodological detailslinear regression models
- Linear regression models
Main finding
As reported in the abstract
- GLP1R-rs10305492-AA/AG genotype combined with a healthy diet, regular physical activity, adequate sleep duration or morning chronotype associated with lower glucose and HbA1c
- all P for trend < 0.001
Further findings
Joint effects of rs10305492 and adequate sleep on hyperglycaemia and high HbA1c
%
- Reduced risk of hyperglycemia (>7.8 mmol/L)
- 26
- Lower risk of high HbA1c (>39 mmol/mol or 5.7 %)
- 22
Original publication
Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c: A gene-environment interaction study. Diabetes Res Clin Pract. Published 12 November 2024. doi:10.
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