Adequacy of pharmacological prescription in patients at very high risk of fracture within the Fracture Liaison Services (FLS) in Spain: analysis of the REFRA FLS-SEIOMM Registry
Authors' conclusion
26.8% of patients were classified as VHRF. Treatment partially aligned with SEIOMM guidelines
Study context
- Population
- Patients aged ≥ 50 years with at least one fragility fracture in the preceding year, treated in 16 FLS in Spain, January 2015 to April 2024of 7161 patients
- Participants
- 1,413 patients
- Exposure
- Very high-risk fracture (VHRF) vs high-risk fracture (HRF)
- VHRFn = 379
- HRFn = 1,034reference
- Outcome
- Classification as HRF or VHRF and alignment of pharmacological treatment with SEIOMM guidelines
Methodological detailsmulticentre, population-based, observational, registry (REFRA FLS-SEIOMM)
- Multicentre
- Population-based
- Observational
- Registry (REFRA FLS-SEIOMM)
Main finding
As reported in the abstract
Classification by fracture risk
- Pharmacological treatment initiated
- 86.5%
Observational data: associations, not effects.
Further findings
Median age
P < 0.001
New fracture · first year
- Patients with a new fracture
- 84 (5.9%)
- 2 or more falls significantly associated with subsequent fractures
Original publication
Adequacy of pharmacological prescription in patients at very high risk of fracture within the FLS in Spain: analysis of the REFRA FLS-SEIOMM Registry. Osteoporos Int. Published 12 September 2025. doi:10.
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