Diabetes complications

Addressing the risk of ocular complications of GLP ‐ 1RAs ; a multi‐disciplinary expert consensus

Diabetes Obes MetabPublished Modified Delphi expert consensus

Methodological detailsmulti-disciplinary, anonymous online Delphi questionnaire, virtual consensus meeting, ACCORD reporting
  • Multi-disciplinary
  • Anonymous online Delphi questionnaire
  • Virtual consensus meeting
  • ACCORD reporting

Recommendations

As issued by the authors

  1. Diabetic retinopathy (DR) worsening events are primarily linked to rapid blood glucose-lowering, rather than a direct drug effect

  2. Benefits of GLP-1 RAs outweigh potential ocular risks and should not limit access to these medicines

  3. Screen people with diabetes for DR before starting GLP-1 RAs, particularly high-risk populations (>10 years duration and/or poor glucose control, HbA1c >10% or 86 mmol/mol)

  4. When prescribing GLP-1 RA to those with sight loss in one eye and/or prior NAION, discuss the risk of ocular complications

Original publication

Addressing the risk of ocular complications of GLP ‐ 1RAs ; a multi‐disciplinary expert consensus. Diabetes Obes Metab. Published 8 October 2025. doi:10.1111/dom.70160

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