Additive Glucagonotropic and Insulinotropic Effects of Glucose‐Dependent Insulinotropic Polypeptide and Alanine in Fasted Healthy Men
Authors' conclusion
In fasting healthy men, both GIP and alanine stimulate pancreatic hormone secretion, and combined administration additively enhances glucagon and C-peptide responses.
Study context
- Population
- Fasted (10-h) healthy men; mean age 22.9 ± 2.82 years, BMI 23.7 ± 2.07 kg/m²crossover, 4 experimental days
- Participants
- 10 participants
- Comparison
- GIP and alanine infusions, alone and combined, vs saline
Methodological detailscrossover, double-blind, placebo-controlled
- Crossover
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Glucagon secretion (bsAUCglucagon) · 90-min infusion
BsAUCglucagon higher
38% ± 5%
P > 0.01
Alanine + GIP vs Alanine + saline
BsAUCglucagon higher
83% ± 7%
P < 0.01
Alanine + GIP vs Saline + GIP
Further findings
| Outcome | P value |
|---|---|
| C-peptideAlanine + GIP vs either single infusion · C-peptide higher with alanine + GIP | P < 0.01 |
| Plasma glucoseSaline + GIP vs Saline + saline · lowered plasma glucose vs placebo | P < 0.01 |
| Plasma glucoseSaline + GIP vs Alanine + saline and Alanine + GIP · lowered plasma glucose | P < 0.01 |
C-peptide
- Saline + GIP transiently raised C-peptide
Original publication
Additive Glucagonotropic and Insulinotropic Effects of Glucose‐Dependent Insulinotropic Polypeptide and Alanine in Fasted Healthy Men. Diabetes Obes Metab. Published 8 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →