The additive effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with and without diabetes: a population-based study
Authors' conclusion
There was a potential additive effect of the TyG index and eGDR on the risk of long-term mortality in individuals with and without diabetes, which provided additional information for prognostic prediction and contributed to improving risk stratification.
Study context
- Population
- Individuals with and without diabetes, National Health and Nutrition Examination Survey (NHANES) 2001–2018
- Participants
- 17,787 individuals
- Exposure
- High triglyceride-glucose (TyG) and low estimated glucose disposal rate (eGDR) vs low TyG and high eGDR
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 8.92 years
Methodological detailspopulation-based, NHANES 2001-2018 linked to National Death Index, multivariate Cox regression and restricted cubic splines
- Population-based
- NHANES 2001-2018 linked to National Death Index
- Multivariate Cox regression and restricted cubic splines
Main finding
As reported in the abstract
High TyG and low eGDR vs Low TyG and high eGDRHazard ratio (95% CI)
All-cause mortality
1.592(1.284–1.975)
Cardiovascular mortality
1.683(1.179–2.400)
- All-cause deaths
- 1946 (10.9%)
- Cardiovascular deaths
- 649 (3.6%)
Observational data: associations, not effects.
Further findings
Dose-response in individuals with diabetes
- Mortality risk increased above TyG (all-cause)
- > 9.04
- Mortality risk increased above TyG (CV)
- > 9.30
- Mortality risk increased below eGDR (all-cause and CV)
- < 4 mg/kg/min
- TyG–mortality association J-shaped; eGDR–mortality L-shaped
Dose-response in individuals without diabetes
- Negative linear association of eGDR with mortality; no association of TyG index with mortality
Combined TyG/eGDR groups in individuals with and without diabetes
- Similar results to overall population
Original publication
The additive effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with and without diabetes: a population-based study. Cardiovasc Diabetol. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →