Adaptive bolus calculators for people with type 1 diabetes: A systematic review
Authors' conclusion
There are limited clinical trials evaluating adaptive bolus calculators. Although results from small trials or in-silico data are promising, further studies are required to support personalized and adaptive management of T1D.
Study context
- Population
- Children or adults with T1D on MDI or insulin pumps; single-arm or randomised controlled studies of adaptive bolus calculators with glycaemic outcomes6 studies
- Comparison
- Adaptive insulin bolus calculators
- Outcome
- Glycaemic outcomes
Methodological detailsdescriptive synthesis, Descriptive synthesis because of heterogeneity, Medline, Embase and Web of Science searched from inception to 13 October 2022; Clinicaltrials.gov searched, Quality assessed with Standard Quality Assessment criteria and Cochrane Risk of Bias tool
- Descriptive synthesis
- Descriptive synthesis because of heterogeneity
- Medline, Embase and Web of Science searched from inception to 13 October 2022; Clinicaltrials.gov searched
- Quality assessed with Standard Quality Assessment criteria and Cochrane Risk of Bias tool
Pooled result
As reported in the abstract
- Overall, studies did not show a significant glycaemic improvement
- Two studies showed a reduction in postprandial TBR or incremental change in blood glucose, in controlled environments over a short duration
- All studies small feasibility studies or not suitably powered; all at high risk of performance and detection bias (unblinded)
Original publication
Adaptive bolus calculators for people with type 1 diabetes: A systematic review. Diabetes Obes Metab. Published 24 July 2023. doi:10.
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