Characterizing insulin dosing behaviour and glycaemic excursions: Development of metrics using connected insulin pen and continuous glucose monitoring
Authors' conclusion
This analysis demonstrates "insulin metrics"-characterizations of insulin dosing behaviour derived from integrated CGM and CIP data-and provides a foundation for future work that will expand the understanding of an individual's insulin self-administration practices and improve clinical decision-making.
Study context
- Population
- Adults with T1D or T2D on MDI insulin therapy with HbA1c ≥8%
- Participants
- 64 adults
- Comparison
- Glucose excursions after pre-meal boluses vs missed, delayed and correction boluses
Methodological details12-week observational study, algorithm development
- 12-week observational study
- Algorithm development
Primary result
As reported in the abstract
Insulin metrics: glucose excursions linked to bolus dosing
- Glycaemic metrics obtained using both algorithms were similar
- Lower %TIR and higher %TAR and %GV on days with missed bolus doses (MBDs)
- Vs pre-meal boluses, delayed and correction boluses followed by excursions with larger change in glucose, longer duration >180 mg/dL, lower post-excursion %TIR and higher post-excursion %TAR
- Excursions following MBDs showed lower %TIR, higher %TAR and lower percent recovery
Further findings
- Glucose excursions larger and longer when continuous glucose monitoring (CGM) was masked than when unmasked
Original publication
Characterizing insulin dosing behaviour and glycaemic excursions: Development of metrics using connected insulin pen and continuous glucose monitoring. Diabetes Obes Metab. Published 10 February 2025. doi:10.
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