Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus
Authors' conclusion
ACR was positively associated with a poor prognosis and mortality at 3-months follow-up after AIS. Subjects included in the 3rd ACR tertile presented a higher risk of poor prognosis and mortality. Baseline glucose or ACR did not add predictive value in comparison to only using classical clinical variables.
Study context
- Population
- Patients admitted for acute ischemic stroke (AIS), with and without DM, Hospital del Mar, Barcelona; ACR = glycemia at admission / eCGL, eCGL = [28.7xHbA1c (%)]-46.7
- Participants
- 2.774 patients
- Exposure
- ACR tertiles
- Outcome
- 3-month poor prognosis (association with ACR)
- Follow-up
- 3 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Poor prognosis (mRS 3-6)
For each 0.1 increase in ACR, increase in the risk of poor outcome
7%
Observational data: associations, not effects.
Further findings
Mortality · 3 months
- 3rd ACR tertile independently associated with mortality
Prediction of AIS prognosis (ROC curves)
- Adding ACR to the classical clinical model did not increase prediction of prognosis (0.786 vs. 0.781)
Factors associated with poor prognosis
- Age, presence of DM, previous disability (mRS), initial severity (NIHSS) and revascularization therapy associated with poor prognosis
- P < 0.05
Original publication
Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus. Cardiovasc Diabetol. Published 18 June 2024. doi:10.
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