The Acute Effects of Real-World Physical Activity on Glycemia in Adolescents With Type 1 Diabetes: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study
Authors' conclusion
Participant-level and activity event-level factors can help predict the magnitude of drop in glucose during real-world physical activity in youth with type 1 diabetes. A better appreciation of these factors may improve decision support tools and self-management strategies to reduce activity-induced dysglycemia in active adolescents living with the disease.
Study context
- Population
- Adolescents with T1D (age 14 ± 2 years; HbA1c 7.1 ± 1.3%; 42% female) self-reporting physical activity, food intake and insulin dosing via smartphone app, with heart rate, CGM and pump data3,738 activities
- Participants
- 251 adolescents
- Outcome
- Glucose during activity
- Follow-up
- Preactivity to end of activity
Main finding
As reported in the abstract
- Preactivity glucose (mean ± SD)
- 163 ± 66 mg/dL (9.1 ± 3.7 mmol/L)
- Glucose at end of activity (mean ± SD)
- 148 ± 66 mg/dL (8.2 ± 3.7 mmol/L)
- Participant-level factors with greater glucose drops: lower baseline HbA1c
- P = 0.002
- Shorter disease duration
- P = 0.02
- Less hypoglycemia fear
- P = 0.04
- Lower BMI
- P = 0.05
- Event-level predictors of greater drops: self-classified "noncompetitive" activities, insulin on board >0.05 units/kg, glucose already dropping before activity, preactivity glucose >150 mg/dL (>8.3 mmol/L), time 70-180 mg/dL >70% in prior 24 h
- all P < 0.001
Observational data: associations, not effects.
Further findings
Activity characteristics
- Median duration of activity (IQR)
- 40 min (20, 75)
- Mean heart rate
- 109 ± 16 bpm
- Peak heart rate
- 130 ± 21 bpm
Original publication
The Acute Effects of Real-World Physical Activity on Glycemia in Adolescents With Type 1 Diabetes: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study. Diabetes Care. Published 3 November 2023. doi:10.
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