Activation of Platelet-derived Growth Factor (PDGF) Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus
Authors' conclusion
We conclude that paracrine signaling in the adult muscle stem cells niche is activated in T2D. Expression analysis of the PDGF-miR-501 signaling pathway could represent a powerful tool to classify patients in clinical trials that aim to improve muscle health and glucose homeostasis in patients with diabetes.
Study context
- Population
- Primary muscle cell cultures from mice and 4 normoglycemic humans; muscle biopsies from patients with T2D and normoglycemic controls
- Participants
- 7 vs 7
- Comparison
- T2D vs normoglycemic controls
- T2Dn = 7
- Normoglycemic controlsn = 7reference
- Outcome
- Expression in skeletal muscle biopsies, T2D vs normoglycemic controls
Main finding
As reported in the abstract
Fold upregulation of PDGF
1.62 fold
P = 0.002
T2D
Fold upregulation of CLCN5-2
2.85 fold
P = 0.03
T2D
Fold upregulation of miR-501
1.73 fold
P = 0.02
T2D
- Positive correlation of PDGF and miR-501 in human skeletal muscle (n = 14), P = .045
- r = 0.542
Original publication
Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 26 January 2023. doi:10.
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