Abnormal Calcium Levels are Associated With Worse Maternal and Fetal Outcomes; Results From an Exploratory Study
Authors' conclusion
Abnormal calcium levels during pregnancy are common and associated with worse pregnancy-related outcomes, which raises the possible need for routine calcium testing. Prospective studies to confirm the incidence, etiology, and effects of abnormal calcium in pregnancy are recommended.
Study context
- Population
- Pregnant women with expected delivery 2017–2019, plus an additional cohort of pregnant women with hypercalcemia (2014–2016 and 2020–2021); single tertiary care maternity unit; median age 30.1 years
- Participants
- 33,118 gestations
- Exposure
- Hypercalcemia or hypocalcemia vs normal calcium in pregnancy
- Hypercalcemian = 42
- Hypocalcemian = 495
- Outcome
- Incidence of hyper- and hypocalcemia when calcium tested
Methodological detailsexploratory, single tertiary care maternity unit
- Exploratory
- Single tertiary care maternity unit
Main finding
As reported in the abstract
- Gestations with albumin-adjusted calcium tested
- 15.7% (n = 5197)
Observational data: associations, not effects.
Further findings
Maternal and fetal outcomes
- Hypercalcemia (incl. additional cohort n = 89) and hypocalcemia associated with increased preterm delivery
- P < 0.001
- Increased emergency cesarean section
- P < 0.001 and .019
- Increased blood loss
- P < 0.001
- Increased neonatal ICU admission
- P < 0.001
Established primary hyperparathyroidism in hypercalcemic group
- Hypercalcemic with established PHPT
- 27%
Original publication
Abnormal Calcium Levels are Associated With Worse Maternal and Fetal Outcomes; Results From an Exploratory Study. J Clin Endocrinol Metab. Published 12 June 2023. doi:10.
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