A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D
Authors' conclusion
The evidence summarized in this systematic review addresses the benefits and harms of vitamin D for the prevention of disease. The guideline panel considered additional information about individuals' and providers' values and preferences and other important decisional and contextual factors to develop clinical recommendations.
Study context
- Population
- General population throughout the lifespan, pregnancy, and adults with prediabetes; 14 clinical questions prioritized by the Endocrine Society guideline panel151 studies
- Comparison
- Vitamin D vs no vitamin D; dosing; screening with serum 25D
Methodological detailsGRADE certainty of evidence, Electronic searches yielded 37 007 citations
- GRADE certainty of evidence
- Electronic searches yielded 37 007 citations
Pooled result
As reported in the abstract
- Children and adolescents: low-certainty evidence suggested reduction in respiratory tract infections with empiric vitamin D
- Healthy adults aged 19 to 74 years: no significant effect on select outcomes (variable certainty)
- Adults older than 75 years: very small reduction in mortality (high certainty)
- Pregnant women: low-certainty evidence suggested possible benefit on various maternal, fetal and neonatal outcomes
- Adults with prediabetes: moderate certainty evidence suggested reduction in rate of progression to diabetes
- No trials identified on benefits and harms of screening with serum 25(OH)D
Safety
- High-dose intermittent vitamin D may increase falls vs lower-dose daily dosing
Original publication
A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D. J Clin Endocrinol Metab. Published 3 June 2024. doi:10.
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