A Randomized Clinical Trial for Meal Bolus Decision Using Learning-based Control in Adults With Type 2 Diabetes
Primary result · TIRResult — go to the resultMedian difference 1.33 % 95% CI −6.00 to 10.94Authors' conclusion
The AP-A-supported physician titration of preprandial insulin dosage offers noninferior glycemic control compared with optimal physician care in type 2 diabetes.
Study context
- Population
- Adults ≥18 years with T2D on multiple dose injection (MDI), HbA1c ≥8.0%, tertiary referral hospital in Beijing, China140 screened
- Participants
- 119 adults
- Comparison
- AP-A-guided preprandial insulin dosing supervised by physician vs conventional physician treatment
- AP-An = 59
- Physiciann = 60reference
- Primary endpoint
- TIR: % time with sensor glucose 3.9 to 10.0 mmol/L
Methodological detailssingle-blind, noninferiority, single-centre (tertiary referral hospital)
- Single-blind
- Noninferiority
- Single-centre (tertiary referral hospital)
Primary result
TIR
Median difference
1.33 %
95% CI −6.00 to 10.94
By group
AP-Avs Physician
median difference 1.33 % (95% CI −6.00 to 10.94)
As reported in the abstract
Safety
| Outcome | AP-A | Physician | Median difference (%) (95% CI) | |
|---|---|---|---|---|
| TBR: % time with sensor glucose <3.0 mmol/LNoninferiority margin 2.0%; noninferior · statistically noninferior | 0.0% (range 0.0%–0.0%) | 0.0% (range 0.0%–0.0%) | 0.00 (0.00%–0.00%) | |
| 0000000Difference, % (linear scale) |
- TBR: % time with sensor glucose <3.0 mmol/L: noninferiority margin 2.0%
Original publication
A Randomized Clinical Trial for Meal Bolus Decision Using Learning-based Control in Adults With Type 2 Diabetes. J Clin Endocrinol Metab. Published 7 March 2024. doi:10.
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