A Novel Method to Evaluate Insulin Sensitivity by Combining Continuous Glucose Monitoring and Urinary C‐Peptide Excretion
Authors' conclusion
These results suggest that the 24 h-glycemia/C-peptide ratio is a promising simple, inexpensive, non-invasive, and physiological marker of insulin sensitivity that deserves further investigation.
Study context
- Population
- Non-diabetic adults (7 women, 6 men; 52.2 ± 13.8 years; BMI 26.1 ± 3.7 kg/m²); 24-h stay in a whole-room indirect calorimeter with continuous glucose monitoring (CGM) (Dexcom G6 Pro) and 24-h urine collection
- Participants
- 13 adults
- Outcome
- Association of the 24 h-glycemia/C-peptide ratio (24-h CGM combined with 24-h urinary C-peptide excretion) with insulin sensitivity by 2-step hyperinsulinemic-euglycemic clamp GIR
Main finding
As reported in the abstract
Association of 24 h-glycemia/C-peptide ratio with clamp GIR
Positive association with low-dose (10 mU/min/m²) GIR, R2 (p = 0.020)
0.401
Trend toward association with high-dose (80 mU/min/m²) GIR, R2 (p = 0.086)
0.266
Observational data: associations, not effects.
Further findings
Association of previously accepted insulin sensitivity markers with clamp GIR
- R2 range, low-dose GIR
- 0.248 to 0.456
- R2 range, high-dose GIR
- 0.108 to 0.174
Original publication
A Novel Method to Evaluate Insulin Sensitivity by Combining Continuous Glucose Monitoring and Urinary C‐Peptide Excretion. Diabetes Obes Metab. Published 4 May 2026. doi:10.
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