A Longitudinal Study of Glucose Tolerance in Cystic Fibrosis: The Central Role of Beta Cell Functional Mass
Authors' conclusion
In subjects with CF, changes in beta cell functional mass are associated with favorable or detrimental changes of glucose tolerance over time.
Study context
- Population
- Subjects with cystic fibrosis (CF) aged 10–25 years with 2 OGTTs over an at least 1-year follow-up
- Participants
- 127 subjects
- Exposure
- Regressors vs stable vs progressors
- Outcome
- Changes in insulin sensitivity (OGIS), insulin clearance and GSIS by glucose tolerance course
- Follow-up
- at least 1-year follow-up
Main finding
As reported in the abstract
- Baseline glucose tolerance and glucose-stimulated insulin secretion (GSIS) changes the only significant predictors of glucose tolerance changes (multinomial logistic regression)
- P < .02, R2 Nagelkerke = 0.55
Observational data: associations, not effects.
Original publication
A Longitudinal Study of Glucose Tolerance in Cystic Fibrosis: The Central Role of Beta Cell Functional Mass. J Clin Endocrinol Metab. Published 12 July 2024. doi:10.
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