A dysregulated bile acids pool is associated with metabolic syndrome and gut microbial dysbiosis in early adolescence
Authors' conclusion
This study suggests that childhood MetS is associated with a dysregulated BA pool and that these alterations could influence the abundance of potentially beneficial bacteria, thus contributing to gut microbial dysbiosis.
Study context
- Population
- Children aged 10 to 12 years with and without metabolic syndrome
- Participants
- 100 children
- Comparison
- Children with metabolic syndrome (MetS) vs controls
- MetSn = 42
- Controlsn = 58reference
- Outcome
- Differences in serum BA levels (LC-MS/MS) and association with gut microbial composition (16S rRNA sequencing)
Main finding
As reported in the abstract
Serum BA levels
Total bile acid (BAs) negatively correlated with gut bacterial diversity (Shannon index)
rho = −0.218
p = 0.035
Observational data: associations, not effects.
Original publication
A dysregulated bile acids pool is associated with metabolic syndrome and gut microbial dysbiosis in early adolescence. Obesity (Silver Spring). Published 4 July 2023. doi:10.
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