A decline in renal function is associated with a reduction in myocardial mechano-energetic efficiency in individuals at high cardiometabolic risk
Authors' conclusion
Our findings demonstrate that a consistent reduction in renal function across eGFR categories is independently associated with reduced myocardial MEEi in individuals with high cardiometabolic risk suggesting that even a mild decline in nearly normal renal function may contribute to altered myocardial energetics.
Study context
- Population
- Adults at high cardiometabolic risk in the CATAnzaro MEtabolic RIsk factors study
- Participants
- 3,572 adults
- Exposure
- Estimated glomerular filtration rate (eGFR) categories G2, G3 and G4 vs G1
- Outcome
- Myocardial mechano-energetic efficiency (MEE) per gram of left ventricular mass (MEEi, mL/sec*g-1) by echocardiography
Main finding
As reported in the abstract
MEEi by eGFR category
- G2, G3 and G4 had significantly reduced MEEi vs G1
- Declining eGFR independently associated with reduced MEEi after adjustment for age, sex, BMI, lipid profile, glucose tolerance, hsCRP, HOMA-IR and glucose-lowering, antihypertensive and lipid-lowering medications (multivariate linear regression)
Observational data: associations, not effects.
Original publication
A decline in renal function is associated with a reduction in myocardial mechano-energetic efficiency in individuals at high cardiometabolic risk. Cardiovasc Diabetol. Published 18 August 2025. doi:10.
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