[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort
Authors' conclusion
This study provides an empiric profiling of the physiological [68 Ga]-DOTATATE avidity of the pituitary gland. The findings suggest that SUV may vary by age and sex and can help guide the use of [68 Ga]-DOTATATE PET/MRI in clinical and research settings. Future studies can build on these findings to investigate further the relationship between pituitary biology and demographic factors.
Study context
- Population
- Patients with a normal pituitary gland undergoing brain [68 Ga]-DOTATATE PET for diagnosis of CNS SSTR2 positive tumors; mean age 58.9, 73% female
- Participants
- 95 patients
- Outcome
- Physiologic [68 Ga]-DOTATATE avidity (maximum SUV, SUVR) and size (MSH) of the normal pituitary gland as a function of age and sex
Main finding
As reported in the abstract
Mean SUV of the pituitary gland (range: 7-59.5, SD = 7.1)
17.6
Mean SUVR of the pituitary gland (range: 3.3-52.6, SD = 7.2)
13.8
Observational data: associations, not effects.
Original publication
[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort. Pituitary. Published 7 June 2023. doi:10.
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