X-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline
Methodological detailsGRADE methodology, 2 systematic reviews, narrative reviews, expert clinical practice survey, 50 international experts (Canada, US, Europe, Asia, South America), methodology experts and a patient partner; 18 teleconferences in 2023-2024
- GRADE methodology
- 2 systematic reviews
- Narrative reviews
- Expert clinical practice survey
- 50 international experts (Canada, US, Europe, Asia, South America), methodology experts and a patient partner; 18 teleconferences in 2023-2024
Recommendations
As issued by the authors
An approach to establishing the diagnosis of X-linked hypophosphatemia (XLH) is presented
GRADEd recommendations on treatment strategies for XLH in children
- weak, very low certainty
Monitoring recommendations, based on clinical practice survey of the International Working Group (IWG) experts
Dental complications addressed, with potential strategies to mitigate them
Original publication
X-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline. J Clin Endocrinol Metab. Published 17 February 2025. doi:10.
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