Weight Loss, Obesity Medication, and Risk of Obesity‐Associated Cancer: A Meta‐Analysis of Randomized Controlled Trials
Pooled result · Overall obesity-related cancerResult — go to the resultRelative risk 1.03 95% CI 0.78–1.37Authors' conclusion
Weight reduction mediated by current AOMs was not associated with a reduced risk of overall or site-specific obesity-associated cancer in patients with overweight or obesity, while a decreased risk of overall obesity-associated cancer was observed in coagonist users.
Study context
- Population
- RCTs of antiobesity medications (AOMs); patients with overweight or obesity
- Participants
- 40,731 participants25 RCTs
- Comparison
- Antiobesity medications vs placebo
- Outcome
- Risk of overall obesity-related cancer
Methodological detailsrandom-effects model, Searched PubMed, Embase, Cochrane CENTRAL, Web of Science and ClinicalTrials.gov from inception to December 2024
- Random-effects model
- Searched PubMed, Embase, Cochrane CENTRAL, Web of Science and ClinicalTrials.gov from inception to December 2024
Pooled result
Overall obesity-related cancer
Relative risk
1.03
95% CI 0.78–1.37
AOMsvs Placebo
RR 1.03 (95% CI 0.78–1.37)
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Overall obesity-related cancer per 5 kg weight reduction mediated by AOMsPer 5 kg weight reduction | 0.97 (0.84–1.12) | |
| Overall obesity-associated cancer, subgroup: coagonists (tirzepatide, cotadutide, cagrilintide)Coagonistsvs PlaceboSubgroup analysis | 0.43 (0.19–0.97) | |
| Overall obesity-associated cancer per 5 kg weight reduction mediated by coagonistsPer 5 kg weight reduction; marginal association · subgroup analysis | 0.79 (0.62–1.00) | |
| 0.20.5125Relative risk (log scale) |
Overall obesity-related cancer per 5 kg weight reduction mediated by AOMs
- Every 5 kg weight reduction not associated with site-specific cancer risk
Original publication
Weight Loss, Obesity Medication, and Risk of Obesity‐Associated Cancer: A Meta‐Analysis of Randomized Controlled Trials. Obesity (Silver Spring). Published 4 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →