Vitamin D Supplementation to Prevent Post‐Thyroidectomy Hypocalcemia
Main finding · Biochemical hypocalcemiaResult — go to the resultOdds ratio 0.28 95% CI 0.11–0.68Authors' conclusion
Although larger randomized trials are needed to confirm these observations, preoperative vitamin D3 was associated with a significant reduction in post-thyroidectomy hypocalcemia in this observational cohort study.
Study context
- Population
- Dutch patients undergoing thyroidectomy; 82.8% female, median age 55 years (IQR 43–66)
- Participants
- 50 vs 154
- Exposure
- Preoperative vitamin D3 vs no supplementation
- Vitamin Dn = 50
- Controln = 154reference
- Outcome
- Incidence of hypocalcemia (albumin-adjusted calcium < 2.00 mmol/L)
- Follow-up
- All postoperative time points
Methodological detailsobservational, historical control cohort (2019-2022)
- Observational
- Historical control cohort (2019-2022)
Main finding
Biochemical hypocalcemia
Odds ratio
0.28
95% CI 0.11–0.68
P = 0.005
Vitamin Dvs Control
OR 0.28 (95% CI 0.11–0.68); P = 0.005
As reported in the abstract
- NNT to prevent one case of hypocalcemia
- five patients
Observational data: associations, not effects.
Further findings
Need for postoperative supplementation
P = 0.007
Time to recover from hypocalcemia
P = 0.002
LOS and readmissions
- No differences were observed in length of hospital stay or readmissions
Original publication
Vitamin D Supplementation to Prevent Post‐Thyroidectomy Hypocalcemia. Clin Endocrinol (Oxf). Published 30 April 2026. doi:10.
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