Visit-to-visit HbA1c variability is associated with aortic stiffness progression in participants with type 2 diabetes
Authors' conclusion
Long-term visit-to-visit HbA1c variability was independently associated with aortic stiffness progression, suggesting that HbA1c variability was a strong predictor of subclinical atherosclerosis in T2D participants.
Study context
- Population
- Participants with T2D in the National Metabolic Management Center (MMC), June 2017 to December 2022
- Participants
- 2,115 participants
- Exposure
- HbA1c and fasting blood glucose (FBG) variability and trajectories vs aortic stiffness progression
- Outcome
- Aortic stiffness progression (increased/persistently high ba-PWV) by two ba-PWV measurements
- Follow-up
- Mean 2.6 years
Methodological detailsmultivariate latent class growth mixed model, logistic regression
- Multivariate latent class growth mixed model
- Logistic regression
Main finding
As reported in the abstract
U-shape class of HbA1c, adjusted OR for increased/persistently high brachial-ankle pulse wave velocity (ba-PWV)
2.17
U-shape class of FBG, adjusted OR for increased/persistently high ba-PWV
1.21
HbA1c variability (coefficient of variation (CV), variability independent of the mean (VIM), successive variation (SV)) significantly associated with aortic stiffness progression, ORs ranging
1.20 to 1.24
Third tertile of HbA1c mean and VIM: higher odds of aortic stiffness progression
78%
95% CI 1.23–2.58
Observational data: associations, not effects.
Further findings
Sensitivity analysis: SD of HbA1c and highest HbA1c variability score (HVS)
- SD of HbA1c and highest HVS significantly associated with adverse outcomes independent of mean HbA1c
Original publication
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