Visceral adipose tissue is associated with changes in leptin, FGF-23 and vitamin D metabolism in chronic kidney disease
Authors' conclusion
Adipose tissue may contribute to altered vitamin D metabolism. This effect appeared primarily related to visceral adipose tissue and the progression towards increased fat in the viscera.
Study context
- Population
- Adults receiving hemodialysis not taking active vitamin D therapy26 at 1 year
- Participants
- 30 adults
- Outcome
- Associations of change in VAT with FGF-23, leptin and vitamin D metabolism
- Follow-up
- 1 year
Methodological detailscohort of clinical trial participants, longitudinal, VAT and subcutaneous adipose tissue (SAT) area by MDCT; vitamin D metabolites by mass spectroscopy; FGF-23, leptin, adiponectin by ELISA, Spearman correlation, Wilcoxon rank-sum tests and linear regression
- Cohort of clinical trial participants
- Longitudinal
- VAT and SAT area by MDCT; vitamin D metabolites by mass spectroscopy; FGF-23, leptin, adiponectin by ELISA
- Spearman correlation, Wilcoxon rank-sum tests and linear regression
Main finding
As reported in the abstract
- Progression towards increased visceral fat (VSR) associated with increased FGF-23 and leptin and decline in 1,25(OH)2D3 to 25(OH)D3 ratio
- Relative change in leptin and leptin to adiponectin ratio associated with change in FGF-23, controlling for baseline FGF-23 and PTH
Observational data: associations, not effects.
Original publication
Visceral adipose tissue is associated with changes in leptin, FGF-23 and vitamin D metabolism in chronic kidney disease. J Bone Miner Res. Published 16 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →