Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture
Authors' conclusion
These results suggest that vascular dysfunction with aging may not be an etiologic mechanism that contributes to the co-occurrence of osteoporosis and cardiovascular disease in older adults.
Study context
- Population
- Individuals in the Framingham Heart Study; vascular function by tonometry and brachial hemodynamic testing, bone density, microarchitecture and strength by HR-pQCT
- Participants
- 1,391 individuals
- Outcome
- Association of increased carotid-femoral pulse wave velocity with cortical bone (HR-pQCT)
Main finding
As reported in the abstract
- Cortical volumetric BMD, tibia: standardized beta
- −0.21 [−0.26, −0.15] (95% CI)
- Cortical volumetric BMD, radius: standardized beta
- −0.20 [−0.26, −0.15] (95% CI)
- Cortical thickness, tibia: standardized beta
- −0.09 [−0.15, −0.04] (95% CI)
- Cortical thickness, radius: standardized beta
- −0.07 [−0.12, −0.01] (95% CI)
- Cortical porosity, tibia: standardized beta
- 0.20 [0.15, 0.25] (95% CI)
- Cortical porosity, radius: standardized beta
- 0.21 [0.15, 0.27] (95% CI)
Observational data: associations, not effects.
Original publication
Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture. J Bone Miner Res. Published 6 May 2024. doi:10.
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