Use of the Glycemia Risk Index at Hybrid Closed-Loop Initiation to Predict Combined International Glucose Targets at 12 Months: Results From the CIRDIA Study Group
Authors' conclusion
M0GRI was significantly associated with M12ESGT status but mostly when in zones A-B or D-E. Hybrid closed-loop training should focus on PwT1D with M0GRI ≥ 41 (90% of M12ESGT- persons), but reaching M12ESGT+ is possible with M0GRI in zones C-D-E (64% of M12ESGT+ persons) and even D-E (20% of M12ESGT+ persons).
Study context
- Population
- Consecutive people with T1D starting hybrid closed-loop (HCL) in a CIRDIA centerM12 data available
- Participants
- 128 people
- Exposure
- M0 glycemia risk index (GRI) thresholds and zones as predictors of combined efficacy and safety glucose targets at 12 months
- Outcome
- ESGT+: Time in range (TIR) >70%, GMI <7%, time below range (TBR)<70 <4% and TBR<54 <1%
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Prediction of M12ESGT+ by M0GRI
| Strategy | Sensitivity | Specificity | PPV | NPV (M0GRI ≥ 61) |
|---|---|---|---|---|
| M0GRI < 41 | 36% | 90% | 74% | — not stated in the abstract |
| M0GRI < 61 | 80% | 56% | — not stated in the abstract | 78% |
Sensitivity
M0GRI < 4136%
M0GRI < 6180%
Specificity
M0GRI < 4190%
M0GRI < 6156%
PPV
M0GRI < 4174%
M0GRI < 61— not stated in the abstract
NPV (M0GRI ≥ 61)
M0GRI < 41— not stated in the abstract
M0GRI < 6178%
— not stated in the abstract
Observational data: associations, not effects.
Further findings
M12ESGT+ by M0GRI zone · 12 months
- Zone A (M0GRI 0 to 20) reaching M12ESGT+
- All
- Drop in % M12ESGT+ per M0GRI zone (A-B-C-D)
- about 25%
- M12ESGT+ in zone E
- 11%
Original publication
Use of the Glycemia Risk Index at Hybrid Closed-Loop Initiation to Predict Combined International Glucose Targets at 12 Months: Results From the CIRDIA Study Group. J Diabetes Sci Technol. Published 5 October 2025. doi:10.
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