Glycemia Risk Index (GRI) and international glucose targets before and 6 months after initiation of hybrid closed loop system in the CIRDIA, a French multisite out-of-hospital center
Authors' conclusion
Setting a GRI threshold at 26 could be helpful to detect with a single number, potentially automatically calculated by CGM platforms, PwT1D who require further support.
Study context
- Population
- Persons with T1D initiating hybrid closed loop (HCL) in the CIRDIA, a French multisite out-of-hospital HCL initiation centersix-month data available
- Participants
- 136 persons
- Exposure
- Ambulatory glucose profile (AGP) metrics at HCL initiation vs 3 and 6 months
- Outcome
- Percentage reaching efficacy and safety targets (EST): TIR >70 %, GMI <7 %, time-below-range (TBR)<70 <4 % and TBR<54 <1 %
- Follow-up
- M0, M3 and M6
Methodological detailsmultisite (n=7), out-of-hospital
- Multisite (n=7)
- Out-of-hospital
Main finding
As reported in the abstract
Reaching EST
Observational data: associations, not effects.
Further findings
| Outcome | M0 | M3 | M6 |
|---|---|---|---|
| GRI | 56.0 ± 20.9 | 30.1 ± 14.1 | 30.6 ± 13.8 |
GRI threshold for detecting patients reaching efficacy and safety targets (EST) (ROC analysis)
- Best GRI threshold
- <26
- Specificity
- 92 %
- NPV
- 93 %
Original publication
Glycemia Risk Index (GRI) and international glucose targets before and 6 months after initiation of hybrid closed loop system in the CIRDIA, a French multisite out-of-hospital center. Diabetes Metab. Published 6 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →