Unraveling the obesity paradox in polytrauma patients: survival benefit specifically in individuals with obesity class I
Main finding · 30-day mortalityResult — go to the resultHazard ratio 0.19 95% CI 0.06–0.66Authors' conclusion
The obesity paradox survival advantage occurs only in polytrauma patients with obesity class I, whereas these with obesity class II tend to have shorter hospital stays.
Study context
- Population
- Polytrauma patients categorized by WHO Asia-Pacific BMI classifications
- Participants
- 1,234 patients
- Exposure
- WHO Asia-Pacific BMI categories
- Outcome
- 30- and 365-day all-cause mortality
- Follow-up
- 30 and 365 days
Methodological detailsinverse probability of treatment weighting, Cox proportional hazards models
- Inverse probability of treatment weighting
- Cox proportional hazards models
Main finding
30-day mortality · 30 days
Hazard ratio
0.19
95% CI 0.06–0.66
P = 0.00864
By group
Obesity class Ivs Normal weight
HR 0.19 (95% CI 0.06–0.66); P = 0.00864
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values | HR (95% CI) | P value | |
|---|---|---|---|---|
| 365-day mortality (primary outcome) · 365 daysObesity class Ivs Normal weightReference group not stated | Underweight 12.5% · Normal weight 15.0% · Overweight 12.6% · Obesity class I 7.5% · Obesity class II 7.7% | 0.57 (0.33–0.99) | P = 0.0448 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Values | P value |
|---|---|---|
| Hospital LOSObesity class II vs Normal weight · significantly shorter with obesity class II | Obesity class II mean 6.08 (SE 7.06) days · Normal weight mean 12.50 (SE 19.80) days | P < 0.001 |
365-day mortality (primary outcome)
- Only obesity class I was associated with a significantly lower risk of 365-day mortality
Original publication
Unraveling the obesity paradox in polytrauma patients: survival benefit specifically in individuals with obesity class I. Obesity (Silver Spring). Published 21 April 2025. doi:10.
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