Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery
Authors' conclusion
Our findings suggest known genetic factors have limited impact on GLP1-RA effectiveness with respect to weight change and confirm treatment efficacy across ancestry groups.
Study context
- Population
- Individuals from 9 multiancestry biobank studies across 6 countries treated with GLP1-RA or bariatric surgery (BS)
- Participants
- 10,960 individuals9 biobank studies
- Comparison
- Known genetic factors vs weight loss after GLP1-RA or BS
- Outcome
- Weight change and its association with known genetic factors
Methodological details9 biobank studies, 6 countries
- 9 biobank studies
- 6 countries
Main finding
As reported in the abstract
Association of genetic factors with weight loss
Higher BMI polygenic score modestly linked to lower weight loss after BS, per s.d. (P = 1.24 × 10-4); effect attenuated in sensitivity analyses
+0.7%
Further findings
| Outcome | GLP1-RA | BS |
|---|---|---|
| Average weight change | average −3.93% or −6.00% | −21.17% |
- Average weight change: GLP1-RA: between 6 and 12 months, depending on outcome definition
- Average weight change: BS: between 6 and 48 months
Average weight change
- Modest ancestry-based differences in GLP1-RA weight change
Original publication
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery. Nat Med. Published 18 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →