Thyroid disease

Unnecessary thyroid surgery rate for suspicious nodule in the absence of molecular testing

Eur Thyroid JPublished Retrospective cohort study

Authors' conclusion

In this real data cohort surgery was unnecessary in more than half of patients with Bethesda III and IV nodules and in 21% of patients with Bethesda V nodules.

Study context

Population
Consecutive patients undergoing fine needle aspiration cytology (FNAC) with rapid on-site evaluation, January 2017–December 2021; 640 females, mean age 54.2 years; 1010 nodules (median size 24.4 mm), 1189 FNAC1,010 nodules
Participants
862 patients
Exposure
Bethesda III vs Bethesda IV vs Bethesda V
Outcome
Rate of unnecessary surgery (surgery for Bethesda III, IV or V results without local compressive symptoms with final benign pathology, and second surgery for completion thyroidectomy) in the absence of molecular testing
Methodological detailssingle-centre, consecutive patients
  • Single-centre
  • Consecutive patients

Main finding

As reported in the abstract

Unnecessary surgery

Observational data: associations, not effects.

Further findings

Surgery performed (benign on pathology)

Benign on pathology

FNAC Bethesda category distribution

Bethesda I, II, III, IV, V, VI
8%, 48%, 17%, 17%, 3%, 6%

EU-TIRADS distribution of nodules

EU-TIRADS 2, 3, 4, 5
3%, 34%, 42%, 22%

Original publication

Unnecessary thyroid surgery rate for suspicious nodule in the absence of molecular testing. Eur Thyroid J. Published 11 October 2023. doi:10.1530/etj-23-0114

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