Uncovering the shared genetic components of thyroid disorders and reproductive health
Authors' conclusion
The study discovers novel genetic loci linked to thyroid phenotypes and highlights the shared genetic determinants between thyroid function and reproductive health, providing evidence for the genetic pleiotropy and shared biological mechanisms between these traits in both sexes.
Study context
- Population
- Individuals of European ancestry from various cohorts; thyroid traits: hyper- and hypothyroidism, TSH levelsup to
- Participants
- 743,088 individuals
- Outcome
- Shared genetic component and relationships between thyroid and reproductive health traits
Methodological detailslarge-scale genetic analysis, genome-wide association study (GWAS) Catalog lookup, gene prioritization, mouse phenotype lookup, genetic correlation analysis
- Large-scale genetic analysis
- GWAS Catalog lookup
- Gene prioritization
- Mouse phenotype lookup
- Genetic correlation analysis
Pooled result
As reported in the abstract
Thyroid lead variants previously linked to reproductive health
50 of 253
Novel thyroid hits linked to reproductive health
5 of 52
Thyroid-associated genes also affecting reproductive phenotypes (most affected functions: genitourinary tract)
31.9%
Original publication
Uncovering the shared genetic components of thyroid disorders and reproductive health. Eur J Endocrinol. Published 27 July 2024. doi:10.
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