Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials
Authors' conclusion
With specific protocols, a variety of tailored approaches can induce type 2 diabetes remission for patients with newly diagnosed type 2 diabetes who are able to subscribe to strict protocols. Consideration of long-term sustainability and effectiveness is needed in future research, along with patient preferences.
Study context
- Population
- Adults with T2D in randomized controlled trials (RCTs) of nonsurgical remission interventions; MEDLINE and Embase (inception to April 2025); 11 countries18 studies
- Comparison
- Nonsurgical T2D remission interventions vs control
- Outcome
- T2D remission
Methodological detailsrandom-effects multilevel meta-analysis, grouped by type of intervention and length of follow-up
- Random-effects multilevel meta-analysis
- Grouped by type of intervention and length of follow-up
Pooled result
As reported in the abstract
Each group vs controlRR for achieving T2D remission (95% CI)
Multimodal interventions
1.75(1.49–2.04)
Nonpharmacological interventions
5.80(4.28–7.87)
Further pooled results
HbA1c change, weight loss and quality of life
- Significant outcomes for intervention vs control groups included change in A1C, weight loss and quality of life
Safety
Hypoglycaemia adverse events
- Improvements in adverse events of hypoglycemia with intervention vs control
Original publication
Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials. Diabetes Care. Published 22 September 2025. doi:10.
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