Type 1 and 2 diabetes mellitus: comprehensive fracture risk relationships in UK Biobank
Authors' conclusion
Diabetes is associated with increased risk of fracture (magnitude of effect greater in type 1 than type 2 diabetes). Associations were partly independent of traditional risk factors, adiposity, eBMD, and CRP. Type 2 diabetes disease duration and the presence of microvascular complications in both types were dose-dependent risk factors for fracture.
Study context
- Population
- UK Biobank participants recruited 2006–2010 at age 40–69 yr; 271,882 women (mean age 56 yr), 227,067 men (57 yr)
- Participants
- 498,949 participants
- Exposure
- T1D or T2D vs no diabetes
- Outcome
- First incident osteoporotic fracture
Methodological detailspopulation-based, UK Biobank, Poisson regression adjusted for clinical risk factors, heel US eBMD, adiposity and C-reactive protein (CRP)
- Population-based
- UK Biobank
- Poisson regression adjusted for clinical risk factors, heel US eBMD, adiposity and CRP
Main finding
As reported in the abstract
Incident osteoporotic fracture
Each group vs no diabetesIncidence rate ratio (95% CI)
Type 1 diabetes
2.93(2.37–3.62)
Type 2 diabetes
1.25(1.14–1.38)
Observational data: associations, not effects.
Further findings
| Outcome | IRR (CI) | |
|---|---|---|
| Fracture risk by microvascular complicationsAny complicationsvs No complications | 2.03 (1.57–2.62) | |
| 0.20.5125Incidence rate ratio (log scale) |
Fracture risk by T2D duration
- Magnitude of risk associated with T2D increased with duration of disease
Fracture risk by microvascular complications
- Increasing number of microvascular complications associated with greater fracture risk
Original publication
Type 1 and 2 diabetes mellitus: comprehensive fracture risk relationships in UK Biobank. J Bone Miner Res. Published 11 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →