Triglycerides and risk of cardiovascular events in statin-treated patients with newly diagnosed type 2 diabetes: a Danish cohort study
Authors' conclusion
In statin-treated patients with newly diagnosed T2DM, triglyceride levels are associated with MACE already from 1.0 mmol/L. This suggests that high triglyceride levels are a predictor of residual cardiovascular risk in early T2DM and could be used to guide allocation of additional lipid-lowering therapies for CVD prevention.
Study context
- Population
- Statin-treated, CVD-naïve patients with newly diagnosed T2D, Northern Denmark 2005–2017; triglycerides assessed within 1 year of diagnosis; median age 63 years, 53% males
- Participants
- 27,080 participants
- Exposure
- Triglyceride levels on statin vs <1.0 mmol/L
- Outcome
- MACE: composite of MI, ischemic stroke or cardiac death
- Follow-up
- From 1 year after T2D diagnosis until 30 April 2021
Methodological detailsCox regression adjusted for confounders
- Cox regression adjusted for confounders
Main finding
As reported in the abstract
Incident MACE
Adjusted hazard ratio (95% CI)
1.0-1.9 mmol/Lvs <1.0 mmol/L
1.14(1.00–1.29)
2.0-2.9 mmol/Lvs <1.0 mmol/L
1.30(1.12–1.51)
≥3.0 mmol/Lvs <1.0 mmol/L
1.44(1.20–1.73)
- Incident major cardiovascular events (MACE) events overall
- 1,957 (11.0 per 1000 person-years)
Observational data: associations, not effects.
Further findings
MACE components and LDL-C adjustment
- Association primarily driven by higher rates of MI and cardiac death; attenuated only slightly after additional adjustment for LDL-C
Spline analyses
- Linearly increasing risk of MACE with higher triglyceride levels
MACE by sex (stratified analyses)
- Associations between triglyceride levels and MACE stronger among women
Original publication
Triglycerides and risk of cardiovascular events in statin-treated patients with newly diagnosed type 2 diabetes: a Danish cohort study. Cardiovasc Diabetol. Published 26 July 2023. doi:10.
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