Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study
Authors' conclusion
Elevated TyG index is significantly associated with the occurrence of CA and higher mortality risk in patients post-CA. Our findings extend the landscape of TyG index in cardiovascular diseases, which requires further prospective cohort study.
Study context
- Population
- Critically ill patients, including patients post-cardiac arrest, eICU Collaborative Research Database; Triglyceride-glucose (TyG) index from triglycerides and glucose within 24 h of intensive care unit (ICU) admission1,021 post-CA
- Participants
- 24,689 patients
- Exposure
- Higher vs lower TyG index
- Outcome
- In-hospital mortality and ICU mortality
Methodological detailsmulticenter, observational, propensity score matching, overlap weighting and inverse probability of treatment weighting (IPTW) sensitivity analyses
- Multicenter
- Observational
- Propensity score matching, overlap weighting and IPTW sensitivity analyses
Main finding
As reported in the abstract
TyG index, in-hospital mortality, multivariate OR
1.28
95% CI 1.03–1.58
TyG index, ICU mortality, multivariate OR
1.27
95% CI 1.02–1.58
Increased TyG index linearly related to higher in-hospital and ICU mortality (restricted cubic spline (RCS)), P for nonlinear
0.225 and 0.271, respectively
Observational data: associations, not effects.
Further findings
| Outcome | Post-CA | Without CA |
|---|---|---|
| TyG index, post-CA vs without CA | 9.20 (unspecified 8.72–9.69) | 8.89 (unspecified 8.45–9.41) |
- TyG index, post-CA vs without cardiac arrest (CA) — Discrimination of CA from overall population, AUC
- 0.625
TyG index, post-CA vs without CA
- TyG index significantly higher post-CA than without CA
Neurological status post-CA
- TyG index negatively correlated with neurological status of patients post-CA
Original publication
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