Triglyceride-glucose index correlates with the occurrence and prognosis of acute myocardial infarction complicated by cardiogenic shock: data from two large cohorts
Authors' conclusion
Elevated TyG index was related to the incidence of CS following AMI and higher mortality risks in the population with AMICS. Our findings pointed a previously undisclosed role of TyG index in regard to AMICS that still requires further validation.
Study context
- Population
- AMI patients from the eICU Collaborative Research Database and MIMIC-IV375 developing CS
- Participants
- 5,208 patients
- Exposure
- AMI patients developing CS vs not developing CS; higher vs lower triglyceride-glucose (TyG) index
- AMICSn = 375
- Outcome
- TyG index
Methodological detailsmulticentre, propensity score matching, inverse probability of treatment weighting and overlap weighting
- Multicentre
- Propensity score matching, inverse probability of treatment weighting and overlap weighting
Main finding
As reported in the abstract
AMICS
9.2
range or interval as printed 8.8–9.7
AMI without CS
9.0
range or interval as printed 8.5–9.5
- Discrimination of AMICS from general AMI by TyG index (AUC)
- 0.604
Observational data: associations, not effects.
Further findings
In-hospital and ICU mortality in AMICS
- TyG index significantly correlated with in-hospital and ICU mortality (logistic analyses)
- Linear link between elevated TyG and increased in-hospital and ICU mortality risk (restricted cubic spline (RCS))
- Increased mortality risk with higher TyG persisted in propensity score matching (PSM)-, overlap weighting (OW)- and inverse probability of treatment weighting (IPTW)-adjusted populations
TyG index and APS score
- Apparent link between TyG index and APS score
Mortality by subgroup
- Stable link between elevated TyG and mortality particularly in older age, females, overweight, hypertensive and those without DM
Original publication
Triglyceride-glucose index correlates with the occurrence and prognosis of acute myocardial infarction complicated by cardiogenic shock: data from two large cohorts. Cardiovasc Diabetol. Published 11 September 2024. doi:10.
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