Triglyceride-glucose index: a novel assessment tool for all-cause mortality in critical stroke patients—a retrospective analysis of the eICU-CRD database
Authors' conclusion
TyG shows stronger correlations with short-term ICU and in-hospital mortality in critically ill stroke patients compared to AIP and TC_HDL. Monitoring TyG may aid prognostic assessment and risk stratification, supporting optimized treatment strategies and aligning with prior research on TyG and stroke outcomes.
Study context
- Population
- ICU-admitted stroke patients (ischemic, hemorrhagic, subarachnoid) from the eICU-CRDscreened
- Participants
- 3,247 patients
- Exposure
- Higher vs lower TyG, atherogenic index of plasma (AIP) and TC_HDL quartiles
- Outcome
- In-hospital and ICU mortality
Methodological detailseICU-CRD database
- eICU-CRD database
Main finding
As reported in the abstract
In-hospital mortality rate
17.2%
ICU mortality rate
9.7%
Elevated TyG and ICU mortality (multivariate Cox), HR
1.528, 95% CI 1.252-1.771
P = 0.002
Elevated TyG and in-hospital mortality (multivariate Cox), HR
1.434, 95% CI 1.04-1.619
P = 0.013
Observational data: associations, not effects.
Further findings
AIP and mortality
- Elevated AIP and ICU mortality, HR
- 1.342, P = 0.021
- Elevated AIP and in-hospital mortality, HR
- 1.631, P = 0.005
- Kaplan-Meier confirmed AIP's association with in-hospital mortality
TC_HDL and mortality
- TC_HDL showed no significant associations
TyG: Kaplan-Meier and restricted cubic splines
- Kaplan-Meier confirmed TyG's links to both mortalities; risk increased with higher TyG
Original publication
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