Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study
Authors' conclusion
This study revealed that cuCTI and changes in CTI are independently associated with the risk of CVD among middle-aged and elderly individuals with elevated cuCTI levels, particularly those with sustained high CTI levels, exhibited a significantly higher risk of CVD. As a cost-effective and accessible tool, cuCTI may provide supplementary information for assessing CVD risk. Monitoring long-term changes in the CTI and maintaining it at relatively low levels may aid early identification of individuals at high risk for CVD.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study
- Participants
- 4,157 participants
- Exposure
- Cumulative CTI quartiles and CTI trajectory groups
- Outcome
- New-onset CVD
Methodological detailsnationwide, longitudinal, China Health and Retirement Longitudinal Study data, K-means clustering of CTI trajectories, restricted cubic spline analysis
- Nationwide
- Longitudinal
- China Health and Retirement Longitudinal Study data
- K-means clustering of CTI trajectories
- Restricted cubic spline analysis
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Q2vs Q1
1.53(1.22–1.92)
Padj < 0.001Q3vs Q1
1.36(1.07–1.74)
Padj = 0.014Persistently high and increasing CTIvs Consistently low CTI
1.31(1.01–1.70)
Padj = 0.041- Participants diagnosed with cardiovascular disease (CVD)
- 609 (13.5%)
- Restricted cubic spline (RCS): linear association between cuCTI and CVD risk
- Padj < 0.05
Observational data: associations, not effects.
Further findings
Subgroup and interaction analyses
- No statistically significant differences across all subgroups
- all p > 0.05
Original publication
Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study. Cardiovasc Diabetol. Published 26 July 2025. doi:10.
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