Trends in homeostasis model assessment of insulin resistance (HOMA-IR) values among South Korean adolescents from 2007–2010 to 2019–2020: a sex-, age-, and weight status-specific analysis
Authors' conclusion
HOMA-IR values should be interpreted considering sex, weight status, and pubertal stages. In particular, during the pubertal period, insulin resistance (IR) can coexist not only due to weight-related factors but also as a result of the distinct hormonal changes characteristic of puberty. Over the 10-year period, the mean HOMA-IR values increased in the group with overweight/obesity during puberty and post-puberty, highlighting the need for active intervention to prevent metabolic complications in adolescents with overweight/obesity.
Study context
- Population
- South Korean adolescents aged 10–18 years, Korean National Health and Nutrition Examination Survey (KNHANES)
- Participants
- 4,621 adolescents
- Exposure
- 2019–2020 vs 2007–2010 survey datasets
- 2019-2020n = 1,148
- 2007-2010n = 3,473reference
- Outcome
- Mean HOMA-IR values and percentile curves by age, sex and weight status
Methodological detailsnationally representative survey (KNHANES IV, V and VIII)
- Nationally representative survey (KNHANES IV, V and VIII)
Main finding
As reported in the abstract
2019-2020
5.21
mean · 95% CI 4.16–6.26
2007-2010
3.25
mean · 95% CI 3.04–3.47
Observational data: associations, not effects.
Further findings
Mean
| Outcome | 2019-2020 | 2007-2010 |
|---|---|---|
| Mean HOMA-IR during puberty, girls | 5.21 (95% CI 3.09–7.33) | 3.58 (95% CI 3.31–3.85) |
HOMA-IR by weight status
- Normal-weight and overweight/obesity both peaked during puberty in both sexes and datasets; overweight/obesity had a higher and wider peak age range
- Mean HOMA-IR did not change in normal-weight adolescents; increased during puberty and post-puberty in boys with overweight/obesity
Original publication
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