Trends in Cardiovascular Disease (CVD) Risk Factors for Youth with Incident Diabetes: SEARCH for Diabetes in Youth
Authors' conclusion
Overall, improvements in CRFs were more often observed in youth with T1D. Youth with T2D had worsening trends over time in BMI z-score, CRP, and kidney function. Further research is needed to better understand these trends and their implications for long-term CVD risk.
Study context
- Population
- Youth aged <20 years with incident diabetes, SEARCH for Diabetes in Youth incident cohorts established 2002–2016
- Participants
- 4,600 vs 932
- Exposure
- Trends in cardiovascular risk factors (CRFs) over incident years, T1D vs T2D
- T1Dn = 4,600
- T2Dn = 932
- Outcome
- Trends over incident year in CRFs (lipids, kidney function, BP z-scores, BMI z-score, WC, CRP)
Methodological detailsincident cohorts 2002–2016, stratified by diabetes type, adjusted for age at diagnosis, sex, race/ethnicity and diabetes duration, interaction analysis by type
- Incident cohorts 2002–2016
- Stratified by diabetes type
- Adjusted for age at diagnosis, sex, race/ethnicity and diabetes duration
- Interaction analysis by type
Main finding
As reported in the abstract
- T1D: all CRFs significantly improved over time, except albumin/creatinine ratio (ACR) > 300, cystatin C, serum creatinine, estimated glomerular filtration rate (eGFR) and C-reactive protein (CRP)
- T2D: Total cholesterol (TC), LDL-c and non-HDL-c significantly improved; eGFR, BMI z-score and CRP significantly worsened
- Significant differences in trends over time by type for TC, HDL-c, BMI z-score, blood pressure (BP) z-scores, waist circumference (WC) and CRP
Observational data: associations, not effects.
Original publication
Trends in CVD Risk Factors for Youth with Incident Diabetes: SEARCH for Diabetes in Youth. Pediatr Diabetes. Published 11 July 2024. doi:10.
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