Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes – A nationwide study in Sweden
An erratum to this article was published (Diabetes Res Clin Pract, Nov 2025 ↗)
Authors' conclusion
Females with T1D have increasing BMI overtime and are heavier than females without T1D. Overweight and obesity are by themselves risk factors for angiopathy.
Study context
- Population
- Females aged 16–35 years with and without T1D, Sweden, January 2005 to October 2015
- Participants
- 3,473 vs 8,487
- Exposure
- Females with T1D vs background population; overweight/obesity vs normal weight in T1D
- T1Dn = 3,473
- Background populationn = 8,487reference
- Outcome
- Time-trends in BMI-distributions; diabetes angiopathy risk with overweight and obesity
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
BMI-distribution
- 90th percentile and median BMI increased equally over time in both groups; T1D started from a higher baseline
- T1D vs Background population: P < 0.001
Observational data: associations, not effects.
Further findings
Any angiopathy in T1D, obesity
- Adj HR, obesity
- 1.37 (CI 1.14-1.64)
- Adjusted Cox regression
Retinopathy in T1D
- Adj HR, overweight
- 1.15 (1.02-1.29)
- Adj HR, obesity
- 1.30 (1.08-1.56)
- Adjusted Cox regression
Original publication
Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes – A nationwide study in Sweden. Diabetes Res Clin Pract. Published 9 September 2023. doi:10.
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