Time in targeted blood glucose range as an independent predictor of 28-Day mortality in ICU Patients: A retrospective study
Main finding · 28-day mortalityResult — go to the resultOdds ratio 0.40 95 % CI 0.22–0.74Authors' conclusion
Time in targeted blood glucose range is independently associated with 28-day mortality in ICU patients, suggesting its potential value as a metric for risk stratification and glycemic management optimization.
Study context
- Population
- Critically ill ICU patients, MIMIC-IV database, stratified into four TIR quartiles
- Participants
- 18,905 patients
- Exposure
- TIR quartiles
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsMIMIC-IV database, multivariable logistic regression
- MIMIC-IV database
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio
0.40
95 % CI 0.22–0.74
P = 0.003
Highest TIR quartilevs Lowest TIR quartile
OR 0.40 (95 % CI 0.22–0.74); P = 0.003
- Per percentage point increase in TIR, fully adjusted
- 0.99 (OR, 95 % CI 0.98-0.99, P < 0.001)
Observational data: associations, not effects.
Further findings
Discriminative ability of predictive model
- AUC
- 0.7543
Original publication
Time in targeted blood glucose range as an independent predictor of 28-Day mortality in ICU Patients: A retrospective study. Diabetes Res Clin Pract. Published 7 February 2025. doi:10.
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