Time-dependent event accumulation in a cardiovascular outcome trial of patients with type 2 diabetes and established atherosclerotic cardiovascular disease
Authors' conclusion
In TECOS, the nonfatal event hazard rates were constant over time. Small increases over time in the hazard rate for fatal events would not require complex modelling to predict event accrual, providing confidence in traditional modelling methods for predicting CV outcome trial event rates in this population. The adjudication gap provides a useful metric to monitor within-trial event accrual patterns.
Study context
- Population
- Patients with T2D and established atherosclerotic CVD in TECOS
Methodological detailscentrally adjudicated events
- Centrally adjudicated events
Primary result
As reported in the abstract
Hazard rate morphology over time for 7 outcomes:
- MACE-4
- Its components
- All-cause mortality
- HF hospitalization
Weibull shape parameter, all-cause mortality
1.14
95% CI 1.08–1.21
Weibull shape parameter, cardiovascular (CV) death
1.08
95% CI 1.01–1.16
Further findings
Adjudication gap (time lag between event occurrence and completed adjudication)
- Adjudication gap improved over the course of the trial
Original publication
Time-dependent event accumulation in a cardiovascular outcome trial of patients with type 2 diabetes and established atherosclerotic cardiovascular disease. Cardiovasc Diabetol. Published 28 March 2023. doi:10.
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