Tight Glycemic Control Can Be Achieved in Adult ICU Patients Safely: Results From a 5-Year Single-Center Observational Study Using the Stochastic TARgeted (STAR) Glycemic Control Framework

J Diabetes Sci TechnolPublished Retrospective observational cohort study

Authors' conclusion

STAR provides safe, effective control for all patients in this large cohort, with minimal hypoglycemia and high nutrition rates. The protocol adapts to patients' specific needs and tolerances, encouraging STAR's adoption in other ICUs. The quality of control also enables prospective assessment of the future of GC's impact on patient outcomes.

Study context

Population
Adult ICU patients treated with STAR glycemic control (GC), Christchurch Hospital ICU, New Zealand, April 2019–December 20241,085 analysed
Participants
1,340 patients
Outcome
Glycaemic control performance
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

GroupValueBlood glucose (BG) measurements in target band
STAR GCmedian 124 (IQR 110–148) mg/dL71%

STAR GC

Valuemedian 124 (IQR 110–148) mg/dL
Blood glucose (BG) measurements in target band71%

Observational data: associations, not effects.

Further findings

Nutrition delivery (%goal feed) and insulin rate

Median [IQR] nutrition delivery, %goal feed
89.0 [17.2-100.0]
Median [IQR] insulin rate, U/h
4.5 [2.0-6.0]

Per-patient consistency

Results were consistent per-patient and improved once in the target band

Safety

Severe hypoglycemia events (BG < 40 mg/dL)
3 (0.21%)
Events unrelated to the control design
2

Original publication

Tight Glycemic Control Can Be Achieved in Adult ICU Patients Safely: Results From a 5-Year Single-Center Observational Study Using the STAR Glycemic Control Framework. J Diabetes Sci Technol. Published 22 January 2026. doi:10.1177/19322968251412857

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