The utility of salivary 11-dehydrodexamethasone as a marker of dexamethasone absorption
Authors' conclusion
The positive relationship between serum DXM and salivary 11-DHD is novel. At higher concentrations of DXM, the correlation becomes somewhat curvilinear and more variable. A similar relationship is seen between salivary cortisol and cortisone. The development of a salivary 11-DHD LC-MS/MS assay has the potential to improve the current patient pathway. Patients could administer the drug and collect a 0900h-saliva sample at their convenience, prior to posting for analysis.
Study context
- Population
- Paired 0900h serum and saliva samples collected post-ONDST
- Participants
- 90 paired samples
- Comparison
- Salivary 11-DHD and salivary dexamethasone (DXM) vs serum DXM after 1 mg overnight dexamethasone suppression test (ONDST)
- Outcome
- Correlation of serum and salivary DXM/11-DHD (Pearson)
- Follow-up
- 0900h post-ONDST
Methodological detailspaired serum and saliva samples, LC-MS/MS
- Paired serum and saliva samples
- LC-MS/MS
Main finding
As reported in the abstract
Serum DXM vs salivary 11-DHD: positive correlation, R-squared
0.75
Serum vs salivary DXM: poor correlation, R-squared
0.135
Salivary DXM vs salivary 11-DHD: poor correlation, R-squared
0.163
Original publication
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