Differences in Clinical Outcomes Between Patients With Incidentally Detected and Clinically Detected Pheochromocytomas and Paragangliomas: A Retrospective Multicenter Study
Authors' conclusion
The detection method was neither associated with short DFS nor a predictor of persistent/recurrent disease, whereas hereditary disease and tumour stage were associated with short DFS and were independent predictors of persistent/recurrent disease in patients with PPGLs.
Study context
- Population
- Patients with PPGLs
- Participants
- 426 patients
- Exposure
- Incidentally detected vs clinically detected PPGL
- Incidentally detectedn = 216
- Clinically detectedn = 210reference
- Outcome
- Disease-free survival (DFS)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Disease-free survival (DFS) did not differ between incidentally and clinically detected PPGLs
- Only hereditary disease and advanced tumour stage were associated with short DFS and were independent predictors of persistent/recurrent disease
Observational data: associations, not effects.
Further findings
Persistent/recurrent disease
- Persistent/recurrent disease, all patients
- 47 (11%)
- Persistent/recurrent disease more common with clinically detected PPGLs
Patient characteristics
- Incidentally detected: older and more normotensive; hypertension and hereditary diseases more common with clinically detected PPGLs
Overall survival
- Incidentally detected PPGLs associated with low overall survival, possibly confounded by age
Original publication
Differences in Clinical Outcomes Between Patients With Incidentally Detected and Clinically Detected Pheochromocytomas and Paragangliomas: A Retrospective Multicenter Study. Clin Endocrinol (Oxf). Published 28 May 2026. doi:10.
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