The Use of EQ-5D for Assessment of Health-Related Quality of Life and Its Determinants in Children with Complex Endocrine Conditions
Authors' conclusion
The EQ-5D can be used in paediatric endocrinology with a clear association with burden of illness as reflected by the complexity of the condition. EQ-5D may represent a useful generic tool for the routine assessment of QoL in paediatric endocrinology.
Study context
- Population
- Children with complex endocrine conditions attending paediatric endocrinology, October 2022–December 2023; M:F 134:82, median age 11.8 years227 EQ-5D questionnaires
- Participants
- 216 children
- Outcome
- EQ-5D health-related quality of life (QoL)
Main finding
As reported in the abstract
- Median visual analogue scale (VAS) (10th, 90th centile)
- 90/100 (65, 100)
- Median dimensions score, <16 years
- 6/15 (5, 10)
- Median dimensions score, >16 years
- 7/15 (5, 9)
- VAS negatively associated with dimensions score; strongest correlation in >16 years
- r = −0.64, p = 0.002
- Best VAS and dimensions scores: Early Puberty
- 99/100 and 5/15
- Worst VAS and dimensions scores: Excess Weight
- 77.5/100 and 8/15
- Multivariate analysis: number of specialities involved over previous year associated with worse VAS score
- p = 0.001
- Multivariate analysis: number of specialities involved over previous year associated with worse dimensions scores
- p < 0.001
Observational data: associations, not effects.
Original publication
The Use of EQ-5D for Assessment of Health-Related Quality of Life and Its Determinants in Children with Complex Endocrine Conditions. Horm Res Paediatr. Published 10 June 2026. doi:10.
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