Impact of Early Initiation of Automated Insulin Delivery on Glycemia Two Years from Type 1 Diabetes Diagnosis
Authors' conclusion
Very high mean TIR at 52 weeks in youth randomized to intensive care with AID soon after T1D diagnosis waned during the 52-week observation period after the randomized trial.
Study context
- Population
- Youth randomized shortly after T1D diagnosis104-week continuous glucose monitoring (CGM) data
- Participants
- 61 vs 52
- Comparison
- RCT intensive care with automated insulin delivery (AID) vs RCT control during the extension
- Intensive caren = 61
- Controln = 52reference
- Primary endpoint
- TIR between groups in the observational extension phase
- Follow-up
- 104 weeks
Methodological detailsobservational extension phase, 52- to 104-week post-diagnosis, At 52 weeks all participants could select their insulin delivery modality; management returned to clinical teams
- Observational extension phase
- 52- to 104-week post-diagnosis
- At 52 weeks all participants could select their insulin delivery modality; management returned to clinical teams
Primary result
Mean %TIR
Mean difference
4 %
95% CI −5% to 13%
P = 0.72
By group
Between RCT intensive care and RCT control
mean difference 4 % (95% CI −5% to 13%); P = 0.72
As reported in the abstract
Further findings
TIR >70% · 104 weeks
P = 0.73
| Outcome | RCT intensive care | RCT control | Mean difference (CI) | P value | |
|---|---|---|---|---|---|
| Mean HbA1c · 104 weeks | mean 6.7 ± 0.7 % | mean 7.2 ± 1.5 % | −0.4 (−1.1 to 0.4) | P = 0.72 | |
| −1.5−1−0.500.5Difference (linear scale) |
| Outcome | RCT intensive care | RCT control |
|---|---|---|
| Mean %TIR at 52 weeks | mean 79 ± 13 % | mean 65% ± 21% |
Mean %time in range (TIR) at 52 weeks
- TIR remained stable in RCT control and declined in RCT intensive care from 52 to 104 weeks
AID use changes during extension
- RCT intensive care participants who discontinued AID
- 3
- Control participants who initiated AID
- 25
Safety
Mean %time <54 mg/dL · 104 weeks
- Remained very low in both groups
- <0.4%
Original publication
Impact of Early Initiation of Automated Insulin Delivery on Glycemia Two Years from Type 1 Diabetes Diagnosis. Horm Res Paediatr. Published 3 June 2026. doi:10.
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