Lipids & metabolic liver disease
The Sex‐Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: An Omics Mendelian Randomization Study
Authors' conclusion
Our findings indicated that RSPO3 could be a drug target for regulating body fat distribution and blood lipids in women.
Study context
- Population
- Sex-stratified genome-wide association study (GWAS) of RSPO3 protein; outcomes body fat and blood lipids
- Participants
- 21,323 vs 18,529
- Comparison
- Genetically predicted RSPO3 protein levels, women vs men
- Womenn = 21,323
- Menn = 18,529
- Outcome
- Associations of RSPO3 protein levels with body fat and blood lipids in women
Methodological detailssex-stratified GWAS, two-sample Mendelian randomization, two-step Mendelian randomization (MR) mediation analysis
- Sex-stratified GWAS
- Two-sample Mendelian randomization
- Two-step MR mediation analysis
Main finding
As reported in the abstract
- Visceral adipose tissue, β (95% CI), women
- 0.22 (0.10 to 0.34)
- Waist circumference, β (95% CI), women
- 0.10 (0.05 to 0.15)
- Hip circumference, β (95% CI), women
- 0.10 (0.05 to 0.15)
- TG, β (95% CI), women
- 0.22 (0.18 to 0.26)
- HDL-C, β (95% CI), women
- −0.17 (−0.21 to −0.13)
- Apolipoprotein A, β (95% CI), women
- −0.11 (−0.15 to −0.06)
Further findings
GWAS loci for RSPO3 protein levels
- Loci associated with RSPO3 protein levels
- 9
- Novel signals
- 3
- Female-stratified loci
- 4
Mediation via sex hormones (two-step MR)
- RSPO3 affected outcomes via SHBG in women, little evidence in men
- 6 outcomes
Original publication
The Sex‐Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: An Omics Mendelian Randomization Study. Obesity (Silver Spring). Published 8 July 2026. doi:10.
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