The relationship between cholesterol levels and thyroid eye disease
Authors' conclusion
Elevated LDL cholesterol may serve as a potential indicator of TED. Further research is needed to determine whether lipid-lowering interventions could reduce TED risk or improve its management.
Study context
- Population
- Graves' disease (GD) patients treated with MMI between 1999 and 2021, Brazil, two tertiary care centres; lipid profile in the euthyroid state
- Outcome
- Association of cholesterol levels with TED activity (clinical activity score) and severity (EUGOGO)
Methodological detailstwo tertiary care centres
- Two tertiary care centres
Main finding
As reported in the abstract
Higher low-density lipoprotein (LDL) cholesterol and increased clinical activity score: OR (95% CI), P
1.012
1.003–1.021P < 0.01
Higher total cholesterol and increased clinical activity score: OR (95% CI), P
1.010
1.002–1.018P < 0.01
Higher LDL cholesterol and more severe disease (EUGOGO): OR (95% CI), P
1.015
1.006–1.024P < 0.01
Higher total cholesterol and more severe disease (EUGOGO): OR (95% CI), P
1.011
1.004–1.019P < 0.005
Observational data: associations, not effects.
Further findings
Thyroid eye disease (TED) activity (multiple regression)
- Correlation with LDL cholesterol
- P < 0.01
- Correlation with smoking status
- P < 0.01
Disease severity (multiple regression)
- Reduced HDL cholesterol: OR (95% CI), P
- 0.973 (0.948-0.999), P < 0.05
- Elevated LDL cholesterol: OR (95% CI), P
- 1.013 (1.004-1.023), P < 0.005
- Active smoking: OR (95% CI), P
- 2.881 (1.190-6.971), P < 0.05
Original publication
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