The Maturity-Onset Diabetes of the Young (MODY) Calculator Overestimates MODY Probability in Hispanic Youth
Authors' conclusion
The MODY risk calculator likely overestimates the probability of MODY in Hispanic youth, largely driven by an overestimation in those not early-insulin treated (predominantly young-onset type 2 diabetes). The calculator needs updating to improve its applicability in this population. In addition, further research is needed to help better identify MODY in Hispanic youth.
Study context
- Population
- Hispanic youth (<23 years) with diabetes, large pediatric tertiary care center in the United States
- Participants
- 2,033 participants
- Exposure
- MODY calculator probability in early-insulin-treated (Cohort 1) vs not early-insulin-treated (Cohort 2) Hispanic youth
- Cohort 1n = 1,566
- Cohort 2n = 467
- Outcome
- MODY probability calculated by the MODY risk calculator
Methodological detailsretrospective chart review, single-centre, large pediatric tertiary care center
- Retrospective chart review
- Single-centre
- Large pediatric tertiary care center
Main finding
As reported in the abstract
Mean MODY probability
- Mean probability, both cohorts combined
- 18.8%
- Expected individuals with MODY
- 382
- Previous estimations (1-5%), ie individuals in this cohort
- 20-102
Observational data: associations, not effects.
Further findings
Positive MODY genetic testing among those tested (clinical suspicion, test availability)
- Tested positive for MODY
- 18
- Tested
- 44 out of 2033 (2.2% of overall cohort)
Original publication
The Maturity-Onset Diabetes of the Young (MODY) Calculator Overestimates MODY Probability in Hispanic Youth. J Clin Endocrinol Metab. Published 4 November 2024. doi:10.
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